Annuaire de la recherche en pneumologie 

Nom du LaboratoireInflammation et Fibrogenese pulmonaires
N° d'équipeINSERM 1152-Equipe 3 – Physiopathologie et épidémiologie des maladies respiratoires
Nom du directeur du laboratoirePretolani Marina
Nom du responsable Pr Bruno Crestani
Courriel du responsablebruno.crestani@aphp.fr
Contacts principauxBRUNO CRESTANI : bruno.crestani@aphp.fr
ARNAUD MAILLEUX (chargé de recherche Inserm): arnaud.mailleux@inserm.fr
AdresseFaculté Xavier Bichat, 16 rie Henri Huchard
CP75018
VilleParis
PaysFrance
Téléphone01 40 25 68 00
Fax01 40 25 88 18
Site internethttp://u1152.e-monsite.com/pages/pages-internes/equipe-3.html
Mots clésfibrose pulmonaire; ARDS; fibroblaste;
RésuméOur aim is to decipher the mechanisms and pathways involved in the development of lung fibrosis, in acute and chronic settings. Our disease models are ARDS, Idiopathic pulmonary fibrosis and connective tissue disease-associated lung fibrosis.
We will address different issues which are a potential source of innovation in this field :
1) We will identify and target the transcription factors (TF) which control the profibrotic phenotype of pulmonary fibroblasts in vitro and in vivo; the developmental and mesenchyme-associated TF PRRX1will be our first target.
2) Lung fibrosis is associated with the reactivation of signaling pathways involved in lung development, including the Fibroblast Growth Factor (FGF)/FGFR pathways. We will explore and manipulate in vivo the antifibrotic potential of the FGF/FGFR4 pathway.
3) Lung cancer is a frequent comorbidity in patients with lung fibrosis. We will characterize the molecular pathways controlling lung cancer in patients and determine how the fibrotic environment drives tumor growth in vitro and in vivo.
4) The genes associated with familial pulmonary fibrosis are identified in a minority of patients. We will identify new genetic susceptibility pathways in lung fibrotic disorders, including familial pulmonary fibrosis and rheumatoid arthritis-associated interstitial lung disease.
Axe principalfibrose pulmonaire; SDRA; cancer bronchopulmonaire

Annuaire de la recherche en pneumologie