Annuaire de la recherche en pneumologie 

Nom du LaboratoireCentre de recherche Cardio-thoracique de Bordeaux. Equipe 2
N° d'équipeu1045
Nom du directeur du laboratoirePatrick Berger
Nom du responsable Pr BERGER Patrick
Courriel du responsablepatrick.berger@u-bordeaux.fr
Contacts principauxthomas.trian@u-bordeaux.fr
AdressePTIB - Hôpital Xavier Arnozan
CP33600
VillePessac
PaysFrance
Téléphone +335 47 30 27 51
Fax
Site internethttp://www.bronchialremodeling.com
Mots clésAsthme-BPCO-Cellule musculaire lisse-Epithélium-Remodelage bronchique-rhinovirus
RésuméThe main project’s goal of the “Bronchial remodeling” team is to understand, evaluate and treat remodeling in bronchial obstructive diseases, such as asthma, chronic obstructive pulmonary disease (COPD) or cystic fibrosis (CF). Indeed, these frequent airway diseases are characterized by bronchial obstruction, inflammation and remodeling. This latter involves, according to various diseases, an increased mass of bronchial smooth muscle (BSM), a peri-bronchial fibrosis and a mucous gland hypertrophy. Mechanisms of BSM remodeling are complex and remain largely unknown. Treatments are still ineffective on it. Moreover, remodeling has been associated with a poor prognosis, high morbidity, and lung function decline.

The main goal of our translational team which associates physiologists, clinicians, pharmacologist, biologists, mycologist and radiologists in a multidisciplinary approach are to:
1. Study the interactions between bronchial epithelium and smooth muscle in
asthma.
2. Identify the role of circulating fibrocytes as a potential source of myofibroblasts infiltrating distal bronchi of COPD patients.
3. Decipher the relationship between fungal and bacterial lung populations, inflammation, remodeling and indoor environment.
4. Develop new noninvasive tools to explore bronchial remodeling in vivo using magnetic resonance imaging (MRI).
Axe principalAsthme BPCO Imagerie Mycobiote

Annuaire de la recherche en pneumologie 

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