|Nom du Laboratoire||Centre de recherche Cardio-thoracique de Bordeaux. Equipe 2|
|Nom du directeur du laboratoire||Patrick Berger|
|Nom du responsable||Pr BERGER Patrick|
|Courriel du email@example.com|
|Adresse||PTIB - Hôpital Xavier Arnozan|
|Téléphone||+335 47 30 27 51|
|Mots clés||Asthme-BPCO-Cellule musculaire lisse-Epithélium-Remodelage bronchique-rhinovirus|
|Résumé||The main project’s goal of the “Bronchial remodeling” team is to understand, evaluate and treat remodeling in bronchial obstructive diseases, such as asthma, chronic obstructive pulmonary disease (COPD) or cystic fibrosis (CF). Indeed, these frequent airway diseases are characterized by bronchial obstruction, inflammation and remodeling. This latter involves, according to various diseases, an increased mass of bronchial smooth muscle (BSM), a peri-bronchial fibrosis and a mucous gland hypertrophy. Mechanisms of BSM remodeling are complex and remain largely unknown. Treatments are still ineffective on it. Moreover, remodeling has been associated with a poor prognosis, high morbidity, and lung function decline.
The main goal of our translational team which associates physiologists, clinicians, pharmacologist, biologists, mycologist and radiologists in a multidisciplinary approach are to:
1. Study the interactions between bronchial epithelium and smooth muscle in
2. Identify the role of circulating fibrocytes as a potential source of myofibroblasts infiltrating distal bronchi of COPD patients.
3. Decipher the relationship between fungal and bacterial lung populations, inflammation, remodeling and indoor environment.
4. Develop new noninvasive tools to explore bronchial remodeling in vivo using magnetic resonance imaging (MRI).
|Axe principal||Asthme BPCO Imagerie Mycobiote|